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Comparison of Hybrid LCMS & Ligand Binding Assays for Bioanalysis, Upcoming Webinar Hosted by Xtalks
Tuesday, April 13, 2021

In this free webinar, the featured speakers will discuss the evolving role of LC-MS/MS in the bioanalysis of large molecule therapeutics and biomarkers. The presentation will provide a comparison between traditional ligand binding assays versus LCMS, and will highlight the advantages of LC-MS/MS to quantitate large molecules. The speakers will also provide a review of case studies highlighting use of both technologies.

TORONTO, April 5, 2021 /PRNewswire-PRWeb/ -- Historically, bioanalytical support for large molecule development has utilized ligand binding (LBA) technologies. The improvement in mass spectrometric technology and growing focus on quantitation of large molecules using liquid chromatography with tandem mass spectrometry (LC-MS/MS) provides an ideal complement to the more established ligand-binding approaches.

LC-MS/MS provides significant advantages to quantitate large molecules. Hybrid mass spectrometry only requires one reagent for enrichment and this reagent does not need to be extremely selective. The detection and selectivity is provided by the mass spectrometer on the back end.

KCAS is a strong advocate of assessing the relative merits of available technologies to answer a project's needs, and using that decision to drive project support. In the past, our ligand binding team provided the majority of our large molecule bioanalysis support. However, more recently, the power and selectivity of LC-MS/MS in large molecule bioanalysis is moving this technology into the mainstream for many PK and biomarker needs.

Register for this live webinar on Friday, April 23, 2021 at 12pm EDT (5pm BST/UK) to hear experts from KCAS Bioanalytical and Biomarker Services, John Perkins, Senior Scientific Advisor and Dawn Dufield, Senior Director, Biopharmaceutical LC-MS/MS Services, discuss the evolving role of LC-MS/MS in the bioanalysis of large molecule therapeutics and biomarkers. They will share how they consider/decide which technology to pursue (LBA vs LCMS), and also present case studies highlighting both.

For more information, or to register for this event, visit Comparison of Hybrid LCMS & Ligand Binding Assays for Bioanalysis.


Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year, thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit
For information about hosting a webinar visit

Media Contact

Ayesha Rashid, Xtalks, +1 (416) 977-6555 x 272,


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