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Worldwide Continuous and Semi-Continuous Bioprocessing Industry to 2030 - COVID-19 Pandemic Has Contributed to Accelerating the Adoption of Continuous Flow Systems
Friday, September 24, 2021
DUBLIN, Sept. 23, 2021 /PRNewswire/ -- The "Continuous and Semi-Continuous Bioprocessing Market by Type of Manufacturer, Company Size, Scale of Operation, Stage of Bioprocess, Geographical Regions: Industry Trends and Global Forecasts, 2021-2030" report has been added to ResearchAndMarkets.com's offering.
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This report features an extensive study on the companies having continuous and semi-continuous bioprocessing capabilities. The study underlines an in-depth analysis, highlighting the diverse capabilities of stakeholders engaged in this domain.
For years, the batch and fed-batch processing technique has been the only available solution for biomanufacturing. However, this method is plagued with several shortcomings, such as process inefficiencies, high risk of human errors and low production speeds. Modern biopharmaceuticals demand faster, and more efficient technologies, preferably with seamless transition into succeeding steps; the primary goal, in this regard, being the preservation of sterility. In other words, a continuous bioprocessing approach is better suited to the needs of the aseptic manufacturing paradigm that is required for biologics. In this context, the introduction of perfusion bioreactors in the late 1980s was a revolutionary development within the industry.
Presently, there are multiple available technologies that are capable of supporting continuous downstream (including clarification / centrifugation, filtration, and chromatography steps) and upstream bioprocesses (which include cell line development and other pre-fermentation steps). A significant number of biopharmaceutical companies, especially certain big pharma players and large contract manufacturing service providers, claim to have already adopted, or are considering installing, continuous bioprocessing technologies, such as perfusion bioreactors, continuous chromatography and continuous filtration equipment. Continuous flow systems have been proven to address a number of challenges associated with traditional bioprocessing; for instance, they facilitate the lowering of manufacturing costs (by 60%), reduction in buffer use (by 30-50%), optimization of resin consumption (by 70%) in chromatography columns, reduction in product change over time (by 90%), improvement of product consistency across different batches (by 50%), minimizing facility footprints (by 50-70%), reduction in operating expenditure (by 90%) and seamless scale up. All the aforementioned advantages eventually serve to improve overall productivity.
The current focus of the users of this novel technology is primarily on upgrading individual operations to the continuous mode; as indicated earlier, some companies have already established bioprocessing lines with multiple continuous processes. Cost, (end product) quality, processing speed and operational flexibility are some of the primary driving factors of the gradual shift to continuous bioprocessing. The COVID-19 pandemic has also contributed to accelerating the adoption of continuous flow systems. Some of the existing challenges in this field include complexities related to defining continuous processes (especially those upstream to the fermentation step), and aligning the available equipment to operate as per current GMP requirements. Although an end-to-end continuous bioproduction line is still several years away, we believe that the opportunity for both innovators and service providers engaged in this domain is likely to grow in the foreseen future.
Amongst other elements, the report includes:
-- A detailed review of the overall landscape of the companies that have
adopted continuous and semi-continuous bioprocessing, including analyses
based on a number of relevant parameters, such as year of establishment,
company size, type of manufacturer (innovator / drug developer and
contract service provider), scale of operation (preclinical, clinical
and commercial), location of headquarters, locations of continuous and
semi-continuous bioprocessing facilities of innovators, locations of
continuous and semi-continuous bioprocessing facilities of contract
service providers, type of facility (modular and conventional), type of
bioreactor (single-use and stainless steel), stage of bioprocess
(upstream and downstream), primary continuous and semi-continuous
bioprocessing (continuous cell culture, continuous clarification /
harvesting, continuous purification, process analytical technology and
others), secondary continuous and semi-continuous bioprocessing (N-1
stage perfusion, N stage perfusion, continuous concentrated fed-batch,
continuous cell retention, continuous centrifugation, continuous
chromatography and continuous viral filtration), types of biologics
manufactured (antibodies, proteins / peptides, vectors, enzymes and
others) and details on the continuous and semi-continuous production
capacity.
-- Tabulated profiles of the key players offering a wide range of services
for the continuous and semi-continuous bioprocessing of products across
North America, Europe and Asia-Pacific. Each profile features a brief
overview of the company, financial information (if available), details
on its service portfolio, continuous and semi-continuous bioprocessing
related capabilities, scale of operation, stage of bioprocess, types of
biologics manufactured, continuous and semi-continuous bioprocessing
manufacturing facilities, recent developments and an informed future
outlook.
-- Key initiatives taken by the leading pharmaceutical companies, taking
into consideration both partnered as well as in-house projects.
-- A case study to depict the overall landscape of the continuous and
semi-continuous bioprocessing equipment providers, based on a number of
parameters, such as type of equipment, type of manufacturing process
(continuous and batch-continuous), stage of bioprocess (upstream process
and downstream process) and scale of operation (preclinical / clinical
and commercial).
-- An insightful analysis highlighting the cost saving potential associated
with the adoption of continuous and semi-continuous bioprocessing
technologies.
-- A detailed analysis to estimate the global, continuous upstream
bioprocessing capacity based on the capacities of various industry
stakeholders. The study includes the distribution of capacity, based on
company size (small, mid-sized and large), type of manufacturer
(innovator / drug developer and contract service provider), scale of
operation (preclinical, clinical and commercial), location of
headquarters (North America, Europe and Asia-Pacific) and location of
continuous and semi-continuous bioprocessing facilities (North America,
Europe and Asia-Pacific).
Key Questions Answered
-- Which are the leading contract manufacturers offering expertise in
continuous bioprocessing?
-- Which are the leading innovators / drug developers with expertise in
continuous bioprocessing?
-- In which regions are majority of the continuous and semi-continuous
bioprocessing facilities located?
-- What is the likely cost saving potential of continuous and
semi-continuous bioprocessing technology?
-- What is the currently installed global capacity for continuous and
semi-continuous bioprocessing?
-- How is the current and future market opportunity likely to be
distributed across key market segments?
Key Topics Covered:
1. PREFACE
2. EXECUTIVE SUMMARY
3. INTRODUCTION
4. MARKET LANDSCAPE
5. CONTINUOUS BIOPROCESSING IN NORTH AMERICA: COMPANY PROFILES
5.1. Chapter Overview
5.2. AGC Biologics
5.2.1. Continuous and Semi-Continuous Bioprocessing Capabilities
5.2.2. Recent Developments and Future Outlook
5.3. Biogen
5.3.1. Continuous and Semi-Continuous Bioprocessing Capabilities
5.3.2. Recent Developments and Future Outlook
5.4. Bristol-Myers Squibb
5.4.1. Continuous and Semi-Continuous Bioprocessing Capabilities
5.4.2. Recent Developments and Future Outlook
5.5. Sanofi Genzyme
5.5.1. Continuous and Semi-Continuous Bioprocessing Capabilities
5.5.2. Recent Developments and Future Outlook
6. CONTINUOUS BIOPROCESSING IN EUROPE: COMPANY PROFILES
6.1. Chapter Overview
6.2. FUJIFILM Diosynth Biotechnologies
6.2.1. Continuous and Semi-Continuous Bioprocessing Capabilities
6.2.2. Recent Developments and Future Outlook
6.3. Merck KGaA
6.3.1. Continuous and Semi-Continuous Bioprocessing Capabilities
6.3.2. Recent Developments and Future Outlook
6.4. Novasep
6.4.1. Continuous and Semi-Continuous Bioprocessing Capabilities
6.4.2. Recent Developments and Future Outlook
6.5. UCB Pharma
6.5.1. Continuous and Semi-Continuous Bioprocessing Capabilities
6.5.2. Recent Developments and Future Outlook
7. CONTINUOUS BIOPROCESSING IN ASIA-PACIFIC: COMPANY PROFILES
7.1. Chapter Overview
7.2. Enzene Biosciences
7.2.1. Continuous and Semi-Continuous Bioprocessing Capabilities
7.2.2. Recent Developments and Future Outlook
7.3. WuXi Biologics
7.3.1. Continuous and Semi-Continuous Bioprocessing Capabilities
7.3.2. Recent Developments and Future Outlook
8. INITIATIVES OF COMPANIES WITH IN-HOUSE CONTINUOUS BIOPROCESSING CAPABILITIES
8.1. Chapter Overview
8.2. Continuous Manufacturing Initiatives of Leading Companies
8.2.1. AbbVie
8.2.1.1. Partnered Initiatives
8.2.1.2. In-House Initiatives
8.2.2. Amgen
8.2.2.1. Partnered Initiatives
8.2.2.2. In-House Initiatives
8.2.3. Bristol-Myers Squibb
8.2.3.1. Partnered Initiatives
8.2.3.2. In-House Initiatives
8.2.4. GlaxoSmithKline
8.2.4.1. Partnered Initiatives
8.2.4.2. In-House Initiatives
8.2.5. Merck
8.2.5.1. Partnered Initiatives
8.2.5.2. In-House Initiatives
8.2.6. Novartis
8.2.6.1. Partnered Initiatives
8.2.6.2. In-House Initiatives
8.2.7. Pfizer
8.2.7.1. Partnered Initiatives
8.2.7.2. In-House Initiatives
8.2.8. Roche
8.2.8.1. Partnered Initiatives
8.2.8.2. In-House Initiatives
8.2.9. Sanofi
8.2.9.1. Partnered Initiatives
8.2.9.2. In-House Initiatives
9. CONTINUOUS MANUFACTURING EQUIPMENT FOR BIOLOGICS: MARKET LANDSCAPE
9.1. Chapter Overview
9.2. Continuous Manufacturing Equipment for Biologic Drugs: Overall Market Landscape
9.2.1. Analysis by Type of Equipment
9.2.2. Analysis by Type of Manufacturing Process
9.2.3. Analysis by Stage of Bioprocess
9.2.4. Analysis by Scale of Operation
9.3. Continuous Manufacturing Equipment Providers for Biologics
9.3.1. Analysis by Year of Establishment
9.3.2. Analysis by Company Size
9.3.3. Analysis by Location of Headquarters
9.3.4. Analysis by Prominent Continuous Manufacturing Equipment Providers
10. COST SAVING ANALYSIS
10.1. Chapter Overview
10.2 Technologies Involved in Continuous and Semi-Continuous Bioprocessing
10.3 Cost Saving Potential of Continuous and Semi-Continuous Bioprocessing
10.3.1. Potential Cost Savings in Upstream Processes
10.3.2. Potential Cost Savings in Downstream Processes
10.4. Key Assumptions and Methodology
10.5 Overall Cost Saving Potential of Continuous and Semi-Continuous Bioprocesses, 2021-2030
10.6 Concluding Remarks
11. CAPACITY ANALYSIS
11.1. Chapter Overview
11.2. Assumptions and Methodology
11.3.1. Global, Continuous and Semi-Continuous Bioprocessing Capacity
11.3.2. Analysis by Company Size
11.3.3. Analysis by Type of Manufacturer
11.3.4. Analysis by Company Size and Type of Manufacturer
11.3.4. Analysis by Scale of Operation
11.3.5. Analysis by Location of Headquarters
11.3.6. Analysis by Location of Continuous and Semi-Continuous Bioprocessing Facilities
12. MARKET FORECAST AND OPPORTUNITY ANALYSIS
12.1. Chapter Overview
12.2. Forecast Methodology and Key Assumptions
12.3. Overall Continuous and Semi-Continuous Bioprocessing Market, 2021-2030
12.4. Continuous Upstream Bioprocessing Market, 2021-2030
12.5. Continuous Downstream Bioprocessing Market, 2021-2030
13. CONCLUSION
14. EXECUTIVE INSIGHTS
14.1. Chapter Overview
14.2. AstraZeneca
14.2.1. Overview of Company / Organization
14.2.2. Interview Transcript: Jon Coffman, Senior Director of Bioprocess Technology and Engineering
14.3. Enzene Biosciences
14.3.1. Overview of Company / Organization
14.3.2. Interview Transcript: Himanshu Gadgil, Director and Chief Scientific Officer
14.4. Albany College of Pharmacy and Health Sciences
14.4.1. Overview of Company / Organization
14.4.2. Interview Transcript: Ehsan Mahdinia, Assistant Professor
15. APPENDIX 1: TABULATED DATA
16. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS
For more information about this report visit https://www.researchandmarkets.com/r/bdt9zc
Media Contact:
Research and Markets
Laura Wood, Senior Manager
press@researchandmarkets.com
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