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Global Duchenne Muscular Dystrophy (DMD) Drugs Market Size, Share & Trends (2018-2023): Analysis by Therapeutic Approach
Friday, November 09, 2018

DUBLIN, Nov 9, 2018 /PRNewswire/ --

The "Duchenne Muscular Dystrophy (DMD) Drugs Market Size, Share & Trends Analysis Report By Therapeutic Approach (Mutation Suppression, Exon Skipping, Steroid Therapy) And Segment Forecasts, 2018 - 2023" report has been added to's offering.

The global duchenne muscular dystrophy (DMD) drugs market size is expected to reach USD 4.11 billion by 2023, expanding at a CAGR of 41.3% during the forecast period. Several factors such as emergence of mutation-specific therapies, growing target population, and favorable government initiatives are driving the market.

The DMD therapeutics market has only three approved products - Exondys51, Translarna, and Emflaza. Increasing uptake of mutation-targeted therapies is likely to boost the sales of branded drugs. However, stringent regulatory procedures and lack of standardized protocol for determination of clinical efficacy are key challenges for the market.

Exon-skipping platform is estimated to hold about 45% of the market share by 2023, driven by increasing adoption of Exondys51 and impending approval of golodirsen and casimersen. Mutation-specific therapies, such as Translarna, are anticipated to face limited adoption due to premium pricing. Associated adverse effects of steroid therapy make them a less favored treatment option.

The DMD drugs market is projected to become intensely competitive in medium- to long-term. The sector has witnessed delays and denials of several key products by the U.S. FDA due to insufficient trials. Raxone (by Santhera) and Givinostat (by Italfarmaco) remain the most strategically significant R&D pipeline assets for the DMD market, with good possibility of regulatory approval during the forecast period.

Launch of late-stage pipeline products is poised to alter the DMD therapeutic landscape in the near future. Several novel mechanisms of action, such as NF-kB inhibition, myostatin inhibition, and gene therapy are under investigation. Other drug classes, such as exon-skipping and mutation-suppression, are expected to gain traction over the forecast period, supported by rising adoption of these therapeutics.

Milo Biotechnology is one of the first companies to venture into gene therapy for DMD. Company's investigational therapy uses an adeno-associated virus as a myostatin inhibitor and is in early stages of development. Wave Life Science's pipeline product is likely to perform 25 times better in terms of clinical efficacy than the existing exon-skipping drugs.

Further key findings from the report suggest:

    --  Exon-skipping platform dominated the therapeutic approaches in 2017,
        capturing nearly 40% of the market. Exondys51 is estimated to be the
        leading drug for DMD by 2023
    --  The U.S. dominated the regional market share and is projected to
        maintain its lead through 2023, owing to rising disease incidence and
        anticipated launch of promising pipeline candidates
    --  Mutation-suppressive therapeutics and steroids are projected to witness
        healthy growth due to increasing adoption of Translarna and Emflaza
    --  Translarna received conditional approval in Europe in 2014 for treatment
        of nonsense mutation DMD patients who are in ambulatory state and are 5
        years or older. Exondys51 and Emflaza have not been approved for DMD
        treatment in Europe
    --  Sarepta, PTC, Santhera, Italfarmaco, and Catabasis are some of the key
        players operating in this arena
    --  Sarepta is poised to lead the market by 2023 due to higher adoption of
        Exondys51 as well as anticipated launch of pipeline candidates

Topics Covered

Chapter 1 Research Methodology
1.1 Information Procurement
1.2 Information or Data Analysis

Chapter 2 Executive Summary

Chapter 3 Disease Primer and Epidemiology
3.1 Disease Primer
3.2 Epidemiology
3.3 Current Prevalence and Incidence for Seven Major Markets (U.S., Japan, EU5)
3.4 Forecast Prevalence and Incidence for Seven Major Markets (U.S., Japan, EU5)

Chapter 4 Global Duchenne Muscular Dystrophy Drugs Market Overview
4.1 Introduction and Market Overview
4.2 Drivers and Challenges
4.3 Deals Landscape (2013-2018)
4.4 Pricing and Reimbursement
4.5 SWOT Analysis

Chapter 5 Duchenne Muscular Dystrophy Drugs Market: Pipeline Intelligence
5.1 Pipeline Landscape
5.2 Late-Stage Pipeline
5.3 Profile of Disruptive Drugs

Chapter 6 Company Profiles
6.1 Sarepta Therapeutics
6.2 PTC Therapeutics
6.3 Santhera Pharmaceuticals
6.4 Italfarmaco
6.5 Catabasis

Chapter 7 Market Outlook
7.1 What the Future Holds
7.2 Winners and Losers
7.3 Emerging Companies
7.4 The Road Ahead

For more information about this report visit

Media Contact:

Research and Markets
Laura Wood, Senior Manager

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SOURCE Research and Markets

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